KPV

Mô tả

KPV is a naturally occurring C-terminal tripeptide (Lys-Pro-Val) derived from alpha-melanocyte stimulating hormone (α-MSH) that retains potent anti-inflammatory properties without melanogenic effects. It primarily works by inhibiting NF-κB nuclear translocation, thereby suppressing pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, and blocking NLRP3 inflammasome activation. Research shows strong efficacy in models of inflammatory bowel disease, colitis, and dermatitis, where it promotes mucosal healing, restores epithelial barrier integrity, and accelerates resolution of inflammation, with particular tropism for intestinal tissue via PepT1 transport. KPV is well-tolerated with minimal side effects and is ideal for IBD, gut barrier repair, chronic inflammation, autoimmune, and dermatological research, often combined with BPC-157 for enhanced GI healing. This content is for research purposes only and is provided solely for reference. It must not be interpreted as health, clinical, or legal advice or guidance.